A Novel, Pan-PDE Inhibitor Exerts Anti-Fibrotic Effects in Human Lung Fibroblasts via Inhibition of TGF-β Signaling and Activation of cAMP/PKA Signaling

Phosphodiesterase (PDE) inhibitors are currently a widespread and extensively studied group of anti-inflammatory and anti-fibrotic compounds which may find use in the treatment of numerous lung diseases, including asthma and chronic obstructive pulmonary disease. Several PDE inhibitors are currently...

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Bibliografiske detaljer
Udgivet i:Int J Mol Sci
Main Authors: Wójcik-Pszczoła, Katarzyna, Chłoń-Rzepa, Grażyna, Jankowska, Agnieszka, Ślusarczyk, Marietta, Ferdek, Paweł E, Kusiak, Agnieszka A, Świerczek, Artur, Pociecha, Krzysztof, Koczurkiewicz-Adamczyk, Paulina, Wyska, Elżbieta, Pękala, Elżbieta, Gosens, Reinoud
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7312375/
https://ncbi.nlm.nih.gov/pubmed/32503342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21114008
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