Zebrafish rbm8a and magoh mutants reveal EJC developmental functions and new 3′UTR intron-containing NMD targets

Many post-transcriptional mechanisms operate via mRNA 3′UTRs to regulate protein expression, and such controls are crucial for development. We show that homozygous mutations in two zebrafish exon junction complex (EJC) core genes rbm8a and magoh leads to muscle disorganization, neural cell death, an...

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Pubblicato in:PLoS Genet
Autori principali: Gangras, Pooja, Gallagher, Thomas L., Parthun, Michael A., Yi, Zhongxia, Patton, Robert D., Tietz, Kiel T., Deans, Natalie C., Bundschuh, Ralf, Amacher, Sharon L., Singh, Guramrit
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7310861/
https://ncbi.nlm.nih.gov/pubmed/32502192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008830
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