The influence of hypoxia and energy depletion on the response of endothelial cells to the vascular disrupting agent combretastatin A-4-phosphate

Combretastatin A-4 phosphate (CA4P) is a microtubule-disrupting tumour-selective vascular disrupting agent (VDA). CA4P activates the actin-regulating RhoA-GTPase/ ROCK pathway, which is required for full vascular disruption. While hypoxia renders tumours resistant to many conventional therapies, lit...

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Udgivet i:Sci Rep
Main Authors: Holmes, Toby, Brown, Andrew W., Suggitt, Marie, Shaw, Lucy A., Simpson, Lucy, Harrity, Joseph P. A., Tozer, Gillian M., Kanthou, Chryso
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7303175/
https://ncbi.nlm.nih.gov/pubmed/32555222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-66568-8
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