Hematopoietic Stem Cell Gene Therapy for Brain Metastases Using Myeloid Cell–Specific Gene Promoters

BACKGROUND: Brain metastases (BrM) develop in 20–40% of cancer patients and represent an unmet clinical need. Limited access of drugs into the brain because of the blood-brain barrier is at least partially responsible for therapeutic failure, necessitating improved drug delivery systems. METHODS: Gr...

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Veröffentlicht in:J Natl Cancer Inst
Hauptverfasser: Andreou, Tereza, Rippaus, Nora, Wronski, Krzysztof, Williams, Jennifer, Taggart, David, Cherqui, Stephanie, Sunderland, Ashley, Kartika, Yolanda D, Egnuni, Teklu, Brownlie, Rebecca J, Mathew, Ryan K, Holmen, Sheri L, Fife, Christopher, Droop, Alastair, Lorger, Mihaela
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2019
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7301153/
https://ncbi.nlm.nih.gov/pubmed/31501884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djz181
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