The RCAN1.4-calcineurin/NFAT signaling pathway is essential for hypoxic adaption of intervertebral discs

Calcipressin-1, also known as regulator of calcineurin 1 (RCAN1), can specifically bind calcineurin at or near the calcineurin A catalytic domain and downregulate calcineurin activity. However, whether RCAN1 affects the hypoxic intervertebral disc (IVD) phenotype through the calcineurin/NFAT signali...

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Publicat a:Exp Mol Med
Autors principals: Huang, Bao, He, Yongqing, Li, Shengwen, Wei, Xiaoan, Liu, Junhui, Shan, Zhi, Huang, Yue, Chen, Jian, Zhao, Fengdong
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7272636/
https://ncbi.nlm.nih.gov/pubmed/32467610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s12276-020-0441-x
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