Peptides as surface coatings of nanoparticles that penetrate human cystic fibrosis sputum and uniformly distribute in vivo following pulmonary delivery

Therapeutic delivery of drug and gene delivery systems have to traverse multiple biological barriers to achieve efficacy. Mucosal administration, such as pulmonary delivery in cystic fibrosis (CF) disease, remains a significant challenge due to concentrated viscoelastic mucus, which prevents drugs a...

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Bibliografiske detaljer
Udgivet i:J Control Release
Main Authors: Leal, Jasmim, Peng, Xiujuan, Liu, Xinquan, Arasappan, Dhivya, Wylie, Dennis C., Schwartz, Sarah H., Fullmer, Jason J., McWilliams, Bennie C., Smyth, Hugh D. C., Ghosh, Debadyuti
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7250722/
https://ncbi.nlm.nih.gov/pubmed/32243979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2020.03.032
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