Peptides as surface coatings of nanoparticles that penetrate human cystic fibrosis sputum and uniformly distribute in vivo following pulmonary delivery

Therapeutic delivery of drug and gene delivery systems have to traverse multiple biological barriers to achieve efficacy. Mucosal administration, such as pulmonary delivery in cystic fibrosis (CF) disease, remains a significant challenge due to concentrated viscoelastic mucus, which prevents drugs a...

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Veröffentlicht in:J Control Release
Hauptverfasser: Leal, Jasmim, Peng, Xiujuan, Liu, Xinquan, Arasappan, Dhivya, Wylie, Dennis C., Schwartz, Sarah H., Fullmer, Jason J., McWilliams, Bennie C., Smyth, Hugh D. C., Ghosh, Debadyuti
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7250722/
https://ncbi.nlm.nih.gov/pubmed/32243979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2020.03.032
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