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The USP14–NLRC5 pathway inhibits titanium particle–induced osteolysis in mice by suppressing NF-κB and PI3K/AKT activities

Total hip arthroplasty (THA) is a widely-used surgical intervention for treating patients with end-stage degenerative and inflammatory osteoarthropathy. However, wear particles from the artificial titanium joint can induce osteolysis, limiting the long-term survivorship of THA. Monocyte/macrophage l...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Fang, Guibin, Fu, Yuan, Li, Shixun, Qiu, Junxiong, Kuang, Manyuan, Lin, Sipeng, Li, Changchuan, Ding, Yue
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7242687/
https://ncbi.nlm.nih.gov/pubmed/32273344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.012495
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