Pyridobenzothiazolones Exert Potent Anti-Dengue Activity by Hampering Multiple Functions of NS5 Polymerase

[Image: see text] Treatment of dengue virus (DENV) and other flavivirus infections is an unmet medical need. The highly conserved flaviviral NS5 RNA-dependent RNA polymerase (RdRp) is an attractive antiviral target that interacts with NS3 and viral RNA within the replication complex assembly. Bioche...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Cannalire, Rolando, Ki Chan, Kitti Wing, Burali, Maria Sole, Gwee, Chin Piaw, Wang, Sai, Astolfi, Andrea, Massari, Serena, Sabatini, Stefano, Tabarrini, Oriana, Mastrangelo, Eloise, Barreca, Maria Letizia, Cecchetti, Violetta, Vasudevan, Subhash G., Manfroni, Giuseppe
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7236247/
https://ncbi.nlm.nih.gov/pubmed/32435384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00619
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