One-leg inactivity induces a reduction in mitochondrial oxidative capacity, intramyocellular lipid accumulation and reduced insulin signalling upon lipid infusion: a human study with unilateral limb suspension

AIMS/HYPOTHESIS: Physical inactivity, low mitochondrial function, increased intramyocellular lipid (IMCL) deposition and reduced insulin sensitivity are common denominators of chronic metabolic disorders, like obesity and type 2 diabetes. Yet, whether low mitochondrial function predisposes to insuli...

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Publicat a:Diabetologia
Autors principals: Bilet, Lena, Phielix, Esther, van de Weijer, Tineke, Gemmink, Anne, Bosma, Madeleen, Moonen-Kornips, Esther, Jorgensen, Johanna A., Schaart, Gert, Zhang, Dongyan, Meijer, Kenneth, Hopman, Maria, Hesselink, Matthijs K. C., Ouwens, D. Margriet, Shulman, Gerald I., Schrauwen-Hinderling, Vera B., Schrauwen, Patrick
Format: Artigo
Idioma:Inglês
Publicat: Springer Berlin Heidelberg 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7228997/
https://ncbi.nlm.nih.gov/pubmed/32185462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-020-05128-1
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