Cleavage of the APE1 N-Terminal Domain in Acute Myeloid Leukemia Cells Is Associated with Proteasomal Activity

Apurinic/apyrimidinic endonuclease 1 (APE1), the main mammalian AP-endonuclease for the resolution of DNA damages through the base excision repair (BER) pathway, acts as a multifunctional protein in different key cellular processes. The signals to ensure temporo-spatial regulation of APE1 towards a...

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Udgivet i:Biomolecules
Main Authors: Lirussi, Lisa, Antoniali, Giulia, Scognamiglio, Pasqualina Liana, Marasco, Daniela, Dalla, Emiliano, D’Ambrosio, Chiara, Arena, Simona, Scaloni, Andrea, Tell, Gianluca
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7226146/
https://ncbi.nlm.nih.gov/pubmed/32244430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom10040531
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