Synthesis and Evaluation of [(18)F]FEtLos and [(18)F]AMBF(3)Los as Novel (18)F-Labelled Losartan Derivatives for Molecular Imaging of Angiotensin II Type 1 Receptors

Losartan is widely used in clinics to treat cardiovascular related diseases by selectively blocking the angiotensin II type 1 receptors (AT(1)Rs), which regulate the renin-angiotensin system (RAS). Therefore, monitoring the physiological and pathological biodistribution of AT(1)R using positron emis...

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Publicado no:Molecules
Main Authors: Sahylí Ortega Pijeira, Martha, Sérgio Gonçalves Nunes, Paulo, Nascimento dos Santos, Sofia, Zhang, Zhengxing, Pérez Nario, Arian, Araujo Perini, Efrain, Miguel Turato, Walter, Rodríguez Riera, Zalua, Chammas, Roger, H. Elsinga, Philip, Lin, Kuo-Shyan, Carvalho, Ivone, Soares Bernardes, Emerson
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7221519/
https://ncbi.nlm.nih.gov/pubmed/32325695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25081872
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