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The Mystery of Rap1 Suppression of Oncogenic Ras

Decades ago, Rap1, a small GTPase very similar to Ras, was observed to suppress oncogenic Ras phenotype, reverting its transformation. The proposed reason, persisting since, has been competition between Ras and Rap1 for a common target. Yet, none was found. There was also Rap1’s puzzling suppression...

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Podrobná bibliografie
Vydáno v:Trends Cancer
Hlavní autoři: Nussinov, Ruth, Jang, Hyunbum, Zhang, Mingzhen, Tsai, Chung-Jung, Sablina, Anna A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7211489/
https://ncbi.nlm.nih.gov/pubmed/32249186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.trecan.2020.02.002
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