RAF kinases are stabilized and required for dendritic cell differentiation and function

RAF kinases (ARAF, BRAF, and CRAF) are highly conserved enzymes that trigger the RAF-MEK1/2-ERK1/2 (MAPK) pathway upon activation of RAS. Despite enormous clinical interest, relatively little is known on the role of RAFs in mediating immune responses. Here, we investigated the role of RAF kinases an...

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Udgivet i:Cell Death Differ
Main Authors: Riegel, Kristina, Schlöder, Janine, Sobczak, Marco, Jonuleit, Helmut, Thiede, Bernd, Schild, Hansjörg, Rajalingam, Krishnaraj
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7206131/
https://ncbi.nlm.nih.gov/pubmed/31541179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-019-0416-4
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