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Long-range Regulation of Partially Folded Amyloidogenic Peptides

Neurodegeneration involves abnormal aggregation of intrinsically disordered amyloidogenic peptides (IDPs), usually mediated by hydrophobic protein-protein interactions. There is mounting evidence that formation of α-helical intermediates is an early event during self-assembly of amyloid-β42 (Aβ42) a...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Bhattacharya, Shayon, Xu, Liang, Thompson, Damien
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7200734/
https://ncbi.nlm.nih.gov/pubmed/32371882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-64303-x
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