Genomic landscape of platinum resistant and sensitive testicular cancers

While most testicular germ cell tumours (TGCTs) exhibit exquisite sensitivity to platinum chemotherapy, ~10% are platinum resistant. To gain insight into the underlying mechanisms, we undertake whole exome sequencing and copy number analysis in 40 tumours from 26 cases with platinum-resistant TGCT,...

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Dades bibliogràfiques
Publicat a:Nat Commun
Autors principals: Loveday, Chey, Litchfield, Kevin, Proszek, Paula Z., Cornish, Alex J., Santo, Flavia, Levy, Max, Macintyre, Geoff, Holryod, Amy, Broderick, Peter, Dudakia, Darshna, Benton, Barbara, Bakir, Maise Al, Hiley, Crispin, Grist, Emily, Swanton, Charles, Huddart, Robert, Powles, Tom, Chowdhury, Simon, Shipley, Janet, O’Connor, Simon, Brenton, James D., Reid, Alison, de Castro, David Gonzalez, Houlston, Richard S., Turnbull, Clare
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7198558/
https://ncbi.nlm.nih.gov/pubmed/32366847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15768-x
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