The Synergistic Interaction of Interferon Types I and II Leads to Marked Reduction in Severe Acute Respiratory Syndrome-Associated Coronavirus Replication and Increase in the Expression of mRNAs for Interferon-Induced Proteins

Interferon (IFN)-α, -β and -γ have been shown to be only marginally effective against severe acute respiratory syndrome coronavirus (SARS-CoV) replication in Vero cell lines. We investigated the combination of type I IFNs (IFN-α or -β) and IFN-γ for antiviral activity and found that such combination...

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Dades bibliogràfiques
Publicat a:Intervirology
Autors principals: Scagnolari, Carolina, Trombetti, Simona, Alberelli, Alessia, Cicetti, Simona, Bellarosa, Daniela, Longo, Roberta, Spanò, Alberto, Riva, Elisabetta, Clementi, Massimo, Antonelli, Guido
Format: Artigo
Idioma:Inglês
Publicat: S. Karger AG 2007
Matèries:
Short Communication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7179537/
https://ncbi.nlm.nih.gov/pubmed/17191018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000098242
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