Anti-Inflammatory and Anti-Migratory Activities of Isoquinoline-1-Carboxamide Derivatives in LPS-Treated BV2 Microglial Cells via Inhibition of MAPKs/NF-κB Pathway

Eleven novel isoquinoline-1-carboxamides (HSR1101~1111) were synthesized and evaluated for their effects on lipopolysaccharide (LPS)-induced production of pro-inflammatory mediators and cell migration in BV2 microglial cells. Three compounds (HSR1101~1103) exhibited the most potent suppression of LP...

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Vydáno v:Int J Mol Sci
Hlavní autoři: Do, Ha Thi Thu, Bui, Bich Phuong, Sim, Seongrak, Jung, Jae-Kyung, Lee, Heesoon, Cho, Jungsook
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7177615/
https://ncbi.nlm.nih.gov/pubmed/32230861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21072319
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