Characterization of cytotoxic T‐lymphocyte epitopes and immune responses to SARS coronavirus spike DNA vaccine expressing the RGD‐integrin‐binding motif

Integrins are critical for initiating T‐cell activation events. The integrin‐binding motif Arg‐Gly‐Asp (RGD) was incorporated into the pcDNA 3.1 mammalian expression vector expressing the codon‐optimized extracellular domain of SARS coronavirus (SARS‐CoV) spike protein, and tested by immunizing C57B...

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Publicado no:J Med Virol
Main Authors: Poh, W.P., Narasaraju, T., Pereira, N.A., Zhong, F., Phoon, M.C., Macary, P.A., Wong, S.H., Lu, J., Koh, D.R., Chow, Vincent T.K.
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley Subscription Services, Inc., A Wiley Company 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7166745/
https://ncbi.nlm.nih.gov/pubmed/19475608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jmv.21571
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