Characterization of cytotoxic T‐lymphocyte epitopes and immune responses to SARS coronavirus spike DNA vaccine expressing the RGD‐integrin‐binding motif

Integrins are critical for initiating T‐cell activation events. The integrin‐binding motif Arg‐Gly‐Asp (RGD) was incorporated into the pcDNA 3.1 mammalian expression vector expressing the codon‐optimized extracellular domain of SARS coronavirus (SARS‐CoV) spike protein, and tested by immunizing C57B...

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Dades bibliogràfiques
Publicat a:J Med Virol
Autors principals: Poh, W.P., Narasaraju, T., Pereira, N.A., Zhong, F., Phoon, M.C., Macary, P.A., Wong, S.H., Lu, J., Koh, D.R., Chow, Vincent T.K.
Format: Artigo
Idioma:Inglês
Publicat: Wiley Subscription Services, Inc., A Wiley Company 2009
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7166745/
https://ncbi.nlm.nih.gov/pubmed/19475608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jmv.21571
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