Potent BRD4 inhibitor suppresses cancer cell-macrophage interaction

Small molecule inhibitor of the bromodomain and extraterminal domain (BET) family proteins is a promising option for cancer treatment. However, current BET inhibitors are limited by their potency or oral bioavailability. Here we report the discovery and characterization of NHWD-870, a BET inhibitor...

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Pubblicato in:Nat Commun
Autori principali: Yin, Mingzhu, Guo, Ying, Hu, Rui, Cai, Wesley L., Li, Yao, Pei, Shiyao, Sun, Hongyin, Peng, Cong, Li, Jiali, Ye, Rui, Yang, Qiaohong, Wang, Nenghui, Tao, Yongguang, Chen, Xiang, Yan, Qin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7156724/
https://ncbi.nlm.nih.gov/pubmed/32286255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15290-0
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