Pumilio proteins utilize distinct regulatory mechanisms to achieve complementary functions required for pluripotency and embryogenesis

Gene regulation in embryonic stem cells (ESCs) has been extensively studied at the epigenetic-transcriptional level, but not at the posttranscriptional level. Pumilio (Pum) proteins are among the few known translational regulators required for stem-cell maintenance in invertebrates and plants. Here...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Uyhazi, Katherine E., Yang, Yiying, Liu, Na, Qi, Hongying, Huang, Xiao A., Mak, Winifred, Weatherbee, Scott D., de Prisco, Nicola, Gennarino, Vincenzo A., Song, Xiaoling, Lin, Haifan
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2020
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7148564/
https://ncbi.nlm.nih.gov/pubmed/32198202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1916471117
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