Cancer-selective Nanoparticles for Combinatorial siRNA Delivery to Primary Human GBM in vitro and in vivo

Novel treatments for glioblastoma (GBM) are urgently needed, particularly those which can simultaneously target GBM cells’ ability to grow and migrate. Herein, we describe a synthetic, bioreducible, biodegradable polymer that can package and deliver hundreds of siRNA molecules into a single nanopart...

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Publicado no:Biomaterials
Main Authors: Kozielski, Kristen L., Ruiz-Valls, Alejandro, Tzeng, Stephany Y., Guerrero-Cázares, Hugo, Rui, Yuan, Li, Yuxin, Vaughan, Hannah J., Gionet-Gonzales, Marissa, Vantucci, Casey, Kim, Jayoung, Schiapparelli, Paula, Al-Kharboosh, Rawan, Quiñones-Hmojosa, Alfredo, Green, Jordan J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7122460/
https://ncbi.nlm.nih.gov/pubmed/31026613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2019.04.020
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