N (1)-Methylpseudouridine substitution enhances the performance of synthetic mRNA switches in cells

Synthetic messenger RNA (mRNA) tools often use pseudouridine and 5-methyl cytidine as substitutions for uridine and cytidine to avoid the immune response and cytotoxicity induced by introducing mRNA into cells. However, the influence of base modifications on the functionality of the RNA tools is poo...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Parr, Callum J C, Wada, Shunsuke, Kotake, Kenjiro, Kameda, Shigetoshi, Matsuura, Satoshi, Sakashita, Souhei, Park, Soyoung, Sugiyama, Hiroshi, Kuang, Yi, Saito, Hirohide
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Synthetic Biology and Bioengineering
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7102939/
https://ncbi.nlm.nih.gov/pubmed/32090264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa070
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