DDX39B interacts with the pattern recognition receptor pathway to inhibit NF-κB and sensitize to alkylating chemotherapy

BACKGROUND: Nuclear factor-κB (NF-κB) plays a prominent role in promoting inflammation and resistance to DNA damaging therapy. We searched for proteins that modulate the NF-κB response as a prerequisite to identifying novel factors that affect sensitivity to DNA damaging chemotherapy. RESULTS: Using...

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Pubblicato in:BMC Biol
Autori principali: Szymura, Szymon J., Bernal, Giovanna M., Wu, Longtao, Zhang, Zhongqin, Crawley, Clayton D., Voce, David J., Campbell, Paige-Ashley, Ranoa, Diana E., Weichselbaum, Ralph R., Yamini, Bakhtiar
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7093963/
https://ncbi.nlm.nih.gov/pubmed/32209106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12915-020-0764-z
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