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ARV-825-induced BRD4 protein degradation as a therapy for thyroid carcinoma
Bromodomain-containing protein 4 (BRD4) is overexpressed in thyroid carcinoma, represents as an important therapeutic target. ARV-825 is a novel cereblon-based PROTAC (Proteolysis Targeting Chsimera) compound. It can induce fast and sustained BRD4 protein degradation. Its potential effect in human t...
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| 出版年: | Aging (Albany NY) |
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| 主要な著者: | , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Impact Journals
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7093165/ https://ncbi.nlm.nih.gov/pubmed/32163373 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.102910 |
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