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Tunable pH-Sensitive 2-Carboxybenzyl Phosphoramidate Cleavable Linkers

We previously described a pH-sensitive phosphoramidate linker scaffold that can be tuned to release amine-containing drugs at various pH values. In these previous studies it was determined that the tunability of this linker was dependent upon the proximity of an acidic group (e.g., carboxylic acid o...

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Bibliografske podrobnosti
izdano v:Tetrahedron Lett
Main Authors: Backer, Brian S., Choy, Cindy J., Davis, Austen L., Browne, Zachery S., Berkman, Clifford E.
Format: Artigo
Jezik:Inglês
Izdano: 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7089582/
https://ncbi.nlm.nih.gov/pubmed/32205898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2020.151650
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