Polarized lung inflammation and Tie2/angiopoietin-mediated endothelial dysfunction during severe Orientia tsutsugamushi infection

Orientia tsutsugamushi infection can cause acute lung injury and high mortality in humans; however, the underlying mechanisms are unclear. Here, we tested a hypothesis that dysregulated pulmonary inflammation and Tie2-mediated endothelial malfunction contribute to lung damage. Using a murine model o...

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Detalhes bibliográficos
Publicado no:PLoS Negl Trop Dis
Main Authors: Trent, Brandon, Liang, Yuejin, Xing, Yan, Esqueda, Marisol, Wei, Yang, Cho, Nam-Hyuk, Kim, Hong-Il, Kim, Yeon-Sook, Shelite, Thomas R., Cai, Jiyang, Sun, Jiaren, Bouyer, Donald H., Liu, Jinjun, Soong, Lynn
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7067486/
https://ncbi.nlm.nih.gov/pubmed/32119672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0007675
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