CDK4/6 inhibition blocks cancer metastasis through a USP51-ZEB1-dependent deubiquitination mechanism

Tumor metastasis is the most common cause of cancer-related deaths, yet it remains poorly understood. The transcription factor zinc-finger E-box binding homeobox 1 (ZEB1) is involved in the epithelial-to-mesenchymal transition (EMT) and plays a pivotal role in tumor metastasis. However, the underlyi...

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Detalhes bibliográficos
Publicado no:Signal Transduct Target Ther
Main Authors: Zhang, Zhen, Li, Jianjun, Ou, Yang, Yang, Guang, Deng, Kaiyuan, Wang, Qiong, Wang, Zhaoyang, Wang, Wenhao, Zhang, Quansheng, Wang, Hang, Sun, Wei, Sun, Peiqing, Yang, Shuang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7064488/
https://ncbi.nlm.nih.gov/pubmed/32296027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41392-020-0118-x
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