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Moderate Fluid Shear Stress Regulates Heme Oxygenase-1 Expression to Promote Autophagy and ECM Homeostasis in the Nucleus Pulposus Cells

In vertebrate, the nucleus pulposus (NP), which is an essential component of the intervertebral disk, is constantly impacted by fluid shear stress (FSS); however, molecular mechanism(s) through which FSS modulates the NP homeostasis is poorly understood. Here we show that FSS regulates the extracell...

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Publicat a:Front Cell Dev Biol
Autors principals: Chen, Sheng, Qin, Lei, Wu, Xiaohao, Fu, Xuekun, Lin, Sixiong, Chen, Di, Xiao, Guozhi, Shao, Zengwu, Cao, Huiling
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2020
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7064043/
https://ncbi.nlm.nih.gov/pubmed/32195253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2020.00127
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