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Moderate Fluid Shear Stress Regulates Heme Oxygenase-1 Expression to Promote Autophagy and ECM Homeostasis in the Nucleus Pulposus Cells

In vertebrate, the nucleus pulposus (NP), which is an essential component of the intervertebral disk, is constantly impacted by fluid shear stress (FSS); however, molecular mechanism(s) through which FSS modulates the NP homeostasis is poorly understood. Here we show that FSS regulates the extracell...

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Bibliografiske detaljer
Udgivet i:Front Cell Dev Biol
Main Authors: Chen, Sheng, Qin, Lei, Wu, Xiaohao, Fu, Xuekun, Lin, Sixiong, Chen, Di, Xiao, Guozhi, Shao, Zengwu, Cao, Huiling
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7064043/
https://ncbi.nlm.nih.gov/pubmed/32195253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2020.00127
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