Targeting protein translation by rocaglamide and didesmethylrocaglamide to treat MPNST and other sarcomas

Malignant peripheral nerve sheath tumors (MPNSTs) frequently overexpress eIF4F components, and the eIF4A inhibitor silvestrol potently suppresses MPNST growth. However, silvestrol has suboptimal drug-like properties, including a bulky structure, poor oral bioavailability (<2%), sensitivity to MDR...

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Udgivet i:Mol Cancer Ther
Main Authors: Chang, Long-Sheng, Oblinger, Janet L., Burns, Sarah S., Huang, Jie, Anderson, Larry W., Hollingshead, Melinda G., Shen, Rulong, Pan, Li, Agarwal, Garima, Ren, Yulin, Roberts, Ryan D., O’Keefe, Barry R., Kinghorn, A. Douglas, Collins, Jerry M.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7056570/
https://ncbi.nlm.nih.gov/pubmed/31848295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-19-0809
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