B cells infected with Type 2 Epstein-Barr virus (EBV) have increased NFATc1/NFATc2 activity and enhanced lytic gene expression in comparison to Type 1 EBV infection

Humans are infected with two distinct strains (Type 1 (T1) and Type 2 (T2)) of Epstein-Barr virus (EBV) that differ substantially in their EBNA2 and EBNA 3A/B/C latency genes and the ability to transform B cells in vitro. While most T1 EBV strains contain the “prototype” form of the BZLF1 immediate-...

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Gepubliceerd in:PLoS Pathog
Hoofdauteurs: Romero-Masters, James C., Huebner, Shane M., Ohashi, Makoto, Bristol, Jillian A., Benner, Bayleigh E., Barlow, Elizabeth A., Turk, Gail L., Nelson, Scott E., Baiu, Dana C., Van Sciver, Nicholas, Ranheim, Erik A., Gumperz, Jenny, Sherer, Nathan M., Farrell, Paul J., Johannsen, Eric C., Kenney, Shannon C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2020
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7046292/
https://ncbi.nlm.nih.gov/pubmed/32059024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008365
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