B cell endosomal RAB7 promotes TRAF6 K63 polyubiquitination and NF-κB activation for antibody class-switching

Upon activation by CD40 or TLR signaling, B lymphocytes activate NF-κB to induce AID and, therefore, immunoglobulin class switch DNA recombination, as central to the maturation of the antibody and autoantibody responses. Here we show that NF-κB activation is boosted by co-localization of engaged imm...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Immunol
Main Authors: Yan, Hui, Fernandez, Maria, Wang, Jingwei, Wu, Shuai, Wang, Rui, Lou, Zheng, Moroney, Justin B., Rivera, Carlos E., Taylor, Julia R., Gan, Huoqun, Zan, Hong, Kolvaskyy, Dmytro, Liu, Dongfang, Casali, Paolo, Xu, Zhenming
Format: Artigo
Jezik:Inglês
Izdano: 2020
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7033007/
https://ncbi.nlm.nih.gov/pubmed/31932498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1901170
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