Co-amorphous solid dispersion systems of lacidipine-spironolactone with improved dissolution rate and enhanced physical stability

Co-amorphous solid dispersion (C-ASD) systems have attracted great attention to improve the solubility of poorly soluble drugs, but the selection of an appropriate stabilizer to stabilize amorphous forms is still a huge challenge. Herein, C-ASD system of two clinical combined used drugs (lacidipine...

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Vydáno v:Asian J Pharm Sci
Hlavní autoři: Wang, Zhaomeng, Sun, Mengchi, Liu, Tian, Gao, Zisen, Ye, Qing, Tan, Xiao, Hou, Yanxian, Sun, Jin, Wang, Dun, He, Zhonggui
Médium: Artigo
Jazyk:Inglês
Vydáno: Shenyang Pharmaceutical University 2019
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7032115/
https://ncbi.nlm.nih.gov/pubmed/32104442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajps.2018.11.001
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