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Dantrolene Attenuates Cardiotoxicity of Doxorubicin Without Reducing its Antitumor Efficacy in a Breast Cancer Model
Dysregulation of calcium homeostasis is a major mechanism of doxorubicin (DOX)-induced cardiotoxicity. Treatment with DOX causes activation of sarcoplasmic reticulum (SR) ryanodine receptor (RYR) and rapid release of Ca(2+) in the cytoplasm resulting in depression of myocardial function. The aim of...
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| Publicado no: | Transl Oncol |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Neoplasia Press
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7031101/ https://ncbi.nlm.nih.gov/pubmed/31918212 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2019.12.006 |
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