Synthetically Lethal Interactions of Heme Oxygenase-1 and Fumarate Hydratase Genes

Elevated expression of heme oxygenase-1 (HO-1, encoded by HMOX1) is observed in various types of tumors. Hence, it is suggested that HO-1 may serve as a potential target in anticancer therapies. A novel approach to inhibit HO-1 is related to the synthetic lethality of this enzyme and fumarate hydrat...

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Bibliografske podrobnosti
izdano v:Biomolecules
Main Authors: Podkalicka, Paulina, Mucha, Olga, Kruczek, Szczepan, Biela, Anna, Andrysiak, Kalina, Stępniewski, Jacek, Mikulski, Maciej, Gałęzowski, Michał, Sitarz, Kamil, Brzózka, Krzysztof, Józkowicz, Alicja, Dulak, Józef, Łoboda, Agnieszka
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2020
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7023083/
https://ncbi.nlm.nih.gov/pubmed/31963199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom10010143
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