Integrative proteomic and functional analyses provide novel insights into the action of the repurposed drug candidate nitroxoline in AsPC-1 cells

We recently identified nitroxoline as a repurposed drug candidate in pancreatic cancer (PC) showing a dose-dependent antiproliferative activity in different PC cell lines. This antibiotic is effective in several in vitro and animal cancer models. To date, the mechanisms of nitroxoline anticancer act...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Veschi, Serena, Ronci, Maurizio, Lanuti, Paola, De Lellis, Laura, Florio, Rosalba, Bologna, Giuseppina, Scotti, Luca, Carletti, Erminia, Brugnoli, Federica, Di Bella, Maria Cristina, Bertagnolo, Valeria, Marchisio, Marco, Cama, Alessandro
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7018951/
https://ncbi.nlm.nih.gov/pubmed/32054977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-59492-4
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