A positive feedback loop between EZH2 and NOX4 regulates nucleus pulposus cell senescence in age-related intervertebral disc degeneration

BACKGROUND: The senescence of nucleus pulposus (NP) cells plays a vital role in the pathogenesis of intervertebral disc (IVD) degeneration (IDD). NADPH oxidase 4 (NOX4)-associated oxidative stress has been shown to induce premature NP cell senescence. Enhancer of zeste homolog 2 (EZH2) is a crucial...

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Bibliografiske detaljer
Udgivet i:Cell Div
Main Authors: Liu, Chang, Liu, Libangxi, Yang, Minghui, Li, Bin, Yi, Jiarong, Ai, Xuezheng, Zhang, Yang, Huang, Bo, Li, Changqing, Feng, Chencheng, Zhou, Yue
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2020
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6995653/
https://ncbi.nlm.nih.gov/pubmed/32025238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13008-020-0060-x
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