Myosin II Reactivation and Cytoskeletal Remodeling as a Hallmark and a Vulnerability in Melanoma Therapy Resistance

Despite substantial clinical benefit of targeted and immune checkpoint blockade-based therapies in melanoma, resistance inevitably develops. We show cytoskeletal remodeling and changes in expression and activity of ROCK-myosin II pathway during acquisition of resistance to MAPK inhibitors. MAPK regu...

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Publicado en:Cancer Cell
Main Authors: Orgaz, Jose L., Crosas-Molist, Eva, Sadok, Amine, Perdrix-Rosell, Anna, Maiques, Oscar, Rodriguez-Hernandez, Irene, Monger, Jo, Mele, Silvia, Georgouli, Mirella, Bridgeman, Victoria, Karagiannis, Panagiotis, Lee, Rebecca, Pandya, Pahini, Boehme, Lena, Wallberg, Fredrik, Tape, Chris, Karagiannis, Sophia N., Malanchi, Ilaria, Sanz-Moreno, Victoria
Formato: Artigo
Idioma:Inglês
Publicado: Cell Press 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6958528/
https://ncbi.nlm.nih.gov/pubmed/31935375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2019.12.003
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