PHD1 controls muscle mTORC1 in a hydroxylation-independent manner by stabilizing leucyl tRNA synthetase

mTORC1 is an important regulator of muscle mass but how it is modulated by oxygen and nutrients is not completely understood. We show that loss of the prolyl hydroxylase domain isoform 1 oxygen sensor in mice (PHD1(KO)) reduces muscle mass. PHD1(KO) muscles show impaired mTORC1 activation in respons...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: D’Hulst, Gommaar, Soro-Arnaiz, Inés, Masschelein, Evi, Veys, Koen, Fitzgerald, Gillian, Smeuninx, Benoit, Kim, Sunghoon, Deldicque, Louise, Blaauw, Bert, Carmeliet, Peter, Breen, Leigh, Koivunen, Peppi, Zhao, Shi-Min, De Bock, Katrien
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6954236/
https://ncbi.nlm.nih.gov/pubmed/31924757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13889-6
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