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Architecture of The Human Ape1 Interactome Defines Novel Cancers Signatures
APE1 is essential in cancer cells due to its central role in the Base Excision Repair pathway of DNA lesions and in the transcriptional regulation of genes involved in tumor progression/chemoresistance. Indeed, APE1 overexpression correlates with chemoresistance in more aggressive cancers, and APE1...
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| Publicat a: | Sci Rep |
|---|---|
| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group UK
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6949240/ https://ncbi.nlm.nih.gov/pubmed/31913336 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-56981-z |
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