Ketamine disinhibits dendrites and enhances calcium signals in prefrontal dendritic spines

A subanesthetic dose of ketamine causes acute psychotomimetic symptoms and sustained antidepressant effects. In prefrontal cortex, the prevailing disinhibition hypothesis posits that N-methyl-d-aspartate receptor (NMDAR) antagonists such as ketamine act preferentially on GABAergic neurons. However,...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Ali, Farhan, Gerhard, Danielle M., Sweasy, Katherine, Pothula, Santosh, Pittenger, Christopher, Duman, Ronald S., Kwan, Alex C.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6946708/
https://ncbi.nlm.nih.gov/pubmed/31911591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13809-8
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