An Activating Mutation in ERK Causes Hyperplastic Tumors in a scribble Mutant Tissue in Drosophila

Receptor tyrosine kinase signaling plays prominent roles in tumorigenesis, and activating oncogenic point mutations in the core pathway components Ras, Raf, or MEK are prevalent in many types of cancer. Intriguingly, however, analogous oncogenic mutations in the downstream effector kinase ERK have n...

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Detalhes bibliográficos
Publicado no:Genetics
Main Authors: Kushnir, Tatyana, Bar-Cohen, Shaked, Mooshayef, Navit, Lange, Rotem, Bar-Sinai, Allan, Rozen, Helit, Salzberg, Adi, Engelberg, David, Paroush, Ze’ev
Formato: Artigo
Idioma:Inglês
Publicado em: Genetics Society of America 2020
Assuntos:
Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6944410/
https://ncbi.nlm.nih.gov/pubmed/31740452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.119.302794
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