Development and Application of a Life-Stage Physiologically Based Pharmacokinetic (PBPK) Model to the Assessment of Internal Dose of Pyrethroids in Humans

To address concerns around age-related sensitivity to pyrethroids, a life-stage physiologically based pharmacokinetic (PBPK) model, supported by in vitro to in vivo extrapolation (IVIVE) was developed. The model was used to predict age-dependent changes in target tissue exposure of 8 pyrethroids; de...

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Vydáno v:Toxicol Sci
Hlavní autoři: Mallick, Pankajini, Moreau, Marjory, Song, Gina, Efremenko, Alina Y, Pendse, Salil N, Creek, Moire R, Osimitz, Thomas G, Hines, Ronald N, Hinderliter, Paul, Clewell, Harvey J, Lake, Brian G, Yoon, Miyoung
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Exposure Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6944222/
https://ncbi.nlm.nih.gov/pubmed/31593217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfz211
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