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Evolving Antibiotics against Resistance: a Potential Platform for Natural Product Development?

To avoid an antibiotic resistance crisis, we need to develop antibiotics at a pace that matches the rate of evolution of resistance. However, the complex functions performed by antibiotics—combining, e.g., penetration of membranes, counteraction of resistance mechanisms, and interaction with molecul...

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Bibliographic Details
Published in:mBio
Main Authors: Wollein Waldetoft, Kristofer, Gurney, James, Lachance, Joseph, Hoskisson, Paul A., Brown, Sam P.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6935861/
https://ncbi.nlm.nih.gov/pubmed/31874919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02946-19
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