Antiarrhythmic Action of Flecainide in Polymorphic Ventricular Arrhythmias Caused by a Gain‐of‐Function Mutation in the Na(v)1.5 Sodium Channel

BACKGROUND: The cardiac sodium channel Na(v)1.5, encoded by the gene SCN5A, is associated with a wide spectrum of hereditary arrhythmias. The gain‐of‐function mutation p.I141V in SCN5A was identified in a large multigenerational family with exercise‐induced polymorphic ventricular arrhythmias. The p...

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Bibliographic Details
Published in:Ann Noninvasive Electrocardiol
Main Authors: Amarouch, Mohamed Y., Swan, Heikki, Leinonen, Jaakko, Marjamaa, Annukka, Lahtinen, Annukka M., Kontula, Kimmo, Toivonen, Lauri, Widen, Elisabeth, Abriel, Hugues
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2015
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6931835/
https://ncbi.nlm.nih.gov/pubmed/26965448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/anec.12312
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