Charge Characteristics of Agouti-Related Protein Implicate Potent Involvement of Heparan Sulfate Proteoglycans in Metabolic Function

The endogenous melanocortin peptide agouti-related protein (AgRP) plays a well-known role in foraging, but its contribution to metabolic regulation is less understood. Mature AgRP((83-132)) has distinct residues for melanocortin receptor binding and heparan sulfate interactions. Here, we show that A...

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Publicado no:iScience
Main Authors: Chen, Jihuan, Chen, Valerie, Kawamura, Tomoya, Hoang, Ivy, Yang, Yang, Wong, Ashley Tess, McBride, Ryan, Repunte-Canonigo, Vez, Millhauser, Glenn L., Sanna, Pietro Paolo
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6928319/
https://ncbi.nlm.nih.gov/pubmed/31863782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2019.10.061
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