Synthesis, anticancer activity, and molecular modeling of 1,4-naphthoquinones that inhibit MKK7 and Cdc25

Cell division cycle 25 (Cdc25) and mitogen-activated protein kinase kinase 7 (MKK7) are enzymes involved in intracellular signaling but can also contribute to tumorigenesis. We synthesized and characterized the biological activity of 1,4-naphthoquinones structurally similar to reported Cdc25 and(or)...

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Bibliographic Details
Published in:Eur J Med Chem
Main Authors: Schepetkin, Igor A., Karpenko, Alexander S., Khlebnikov, Andrei I., Shibinska, Marina O., Levandovskiy, Igor A., Kirpotina, Liliya N., Danilenko, Nadezhda V., Quinn, Mark T.
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6925601/
https://ncbi.nlm.nih.gov/pubmed/31563013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2019.111719
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