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Comparison of Gene Delivery to the Kidney by Adenovirus, Adeno-Associated Virus, and Lentiviral Vectors After Intravenous and Direct Kidney Injections

There are many kidney diseases that might be addressed by gene therapy. However, gene delivery to kidney cells is inefficient. This is due, in part, to the fact that the kidney excludes molecules above 50 kDa and that most gene delivery vectors are megaDaltons in mass. We compared the ability of ade...

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Detalhes bibliográficos
Publicado no:Hum Gene Ther
Main Authors: Rubin, Jeffrey D., Nguyen, Tien V., Allen, Kari L., Ayasoufi, Katayoun, Barry, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc., publishers 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6919283/
https://ncbi.nlm.nih.gov/pubmed/31637925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2019.127
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